Compassionate use of Pulmonary Vasodilators in Acute Severe Hypoxic Respiratory Failure due to COVID-19COVID-19로 인한 급성 중증 저산소성 호흡부전에서 폐혈관 확장제의 자비로운 사용Article Published on 2022-08-012022-09-11 Journal: Journal of Intensive Care Medicine [Category] COVID19(2023년), SARS, 신약개발, [키워드] acute hypoxic respiratory failure Adult patients analysed ARDS changes in Cohort cohort of patient collected data commenced COVID-19 death Evidence failure feasible Gradient hospital hypoxaemia hypoxic respiratory failure ICU ICU admission Iloprost implementation Inhaled intensive care intensive care unit lack less median nitric oxide non-survivor Non-survivors offer outcome Oxygenation PaO Patient patients with COVID-19 patients with SARS-CoV-2 PF ratio Potential treatment Primary outcome protocol pulmonary Pulmonary vasodilators. randomised receiving reduction in respiratory Respiratory failure robust severe COVID-19 significantly study period Support survivor the median therapeutic option therapeutic options therapy trials vasodilator [DOI] 10.1177/08850666221086521 PMC 바로가기 [Article Type] Article
Mortality Predictors in Severe SARS-CoV-2 InfectionObservational Study Published on 2022-07-182022-10-05 Journal: Medicina [Category] COVID19(2023년), SARS, 임상, [키워드] Admission age Algorithm changes in Cluster Clusters Community COVID-19 CT scan density clusters element evaluate evaluated Evolution form hemoglobin high mortality hospital hypoxic respiratory failure IMPROVE include increase interstitial lactate dehydrogenase lesions less lung lung involvement lung lesion Lymphocytes material Mortality Myoglobin non-survivor Non-survivors objective Observational cohort study oxygen flow PaO parameter parameters Patient performed Platelets Prediction score Predictive predictor Prognosis pulmonary involvement pulmonary lesion Quantitative quantitative evaluation radiological raising Regression model Result retrospective risk factor risk factor. SARS-CoV-2 SARS-CoV-2 pneumonia semi-quantitative Sensitivity and specificity serum albumin serum creatinine Severe case severe COVID-19 Survivors [DOI] 10.3390/medicina58070945 PMC 바로가기 [Article Type] Observational Study
Dynamic blood oxygen indices in mechanically ventilated COVID-19 patients with acute hypoxic respiratory failure: A cohort studyObservational Study Published on 2022-06-102022-10-04 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 임상, [키워드] Admission adult COVID-19 patient adult COVID-19 patients age AHRF analysed averaged baseline characteristics Blood blood oxygen BMI changes in Clinical outcome clinical outcomes clinical variable cohort of patient cohort study collected COVID-19 COVID-19 patient COVID-19 patients dynamic evaluate evaluated exhibited exploratory study hallmark help homogenous hypoxaemia hypoxic hypoxic respiratory failure IMPROVE intensive care Invasive mechanical ventilation IQR kPa less majority mean difference mechanical ventilation mechanically ventilated men morbidity and mortality non-survivor Non-survivors Observational cohort study offer outcome oxygen PaO2 PaO2/FiO2 ratio Patient performed retrospective Severe COVID-19 pneumonia significantly higher significantly lower supplementary oxygen survival survivor therapy understanding unique while [DOI] 10.1371/journal.pone.0269471 PMC 바로가기 [Article Type] Observational Study
Impact of covid-19 on long-term oxygen therapy 2020: A nationwide study in SwedenObservational Study Published on 2022-04-082022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] cause caused Characteristics characteristics of patient failure Hypoxemia hypoxic respiratory failure Impact incidence infections information less majority material outbreak Oxygen therapy pandemic Patient provided reduction in registry respiratory significant difference [DOI] 10.1371/journal.pone.0266367 PMC 바로가기 [Article Type] Observational Study
All-cause mortality in COVID-19 patients receiving statin therapy: analysis of veterans affairs database cohort studyObservational Study Published on 2022-04-012022-10-05 Journal: Internal and Emergency Medicine [Category] 임상, [키워드] 95% CI 95% confidence interval Admission all-cause mortality Analysis antecedent association Cohort cohort study Comorbidity coronavirus covariates COVID-19 COVID-19 diagnosis COVID-19 patient Cox proportional hazard database decreased mortality defined demonstrated diagnosed with COVID-19 greater higher risk hypoxic respiratory failure ICU ICU admission intensive care Logistic regression Mechanical mechanical ventilation median age men Mortality Patient patients with COVID-19 positive Potential treatment Prevalence receiving reducing respiratory Respiratory failure risk statin statins statins. stratified study population tested warehouse was performed [DOI] 10.1007/s11739-021-02848-z PMC 바로가기 [Article Type] Observational Study
COVID-19 and Bradyarrhythmias: A Case Report With Literature ReviewCardiology Published on 2022-01-242022-10-31 Journal: Cureus [Category] COVID-19, [키워드] arrhythmia bradyarrhythmia bradycardia Case report case sery Complete heart block COVID-19 COVID-19 infection COVID-19 patients Hospitalization hypoxic respiratory failure infected with COVID-19 literature male pacemaker past medical history Patient patient with COVID-19 report review sinus arrest sinus pause sinus pauses the patient [DOI] 10.7759/cureus.21552 PMC 바로가기 [Article Type] Cardiology
When stem cells meet COVID-19: recent advances, challenges and future perspectivesReview Published on 2022-01-102022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, SARS, [키워드] acute respiratory distress approaches caused Cell clinically Coronavirus disease 2019 COVID-19 COVID-19 pandemic develop disease effective global public health hypoxic respiratory failure lack Mortality MSCs multiple organ failure Organoid models Perspective provide rate of infection Research Respiratory Coronavirus SARS-CoV-2 stem cell Stem cell therapy Stem cell threapy supportive care syndrome systematic review Therapies Treatment [DOI] 10.1186/s13287-021-02683-1 PMC 바로가기 [Article Type] Review
Pulmonary aspergillosis and cryptococcosis as a complication of COVID-19Case Report Published on 2022-01-062022-10-29 Journal: Medical Mycology Case Reports [Category] COVID-19, [키워드] Aspergillus Bronchoalveolar lavage CAPA Comorbidities Comorbidity complicate complication of COVID-19 Corticosteroid COVID-19 Critical Cryptococcus Culture Cyclophosphamide diagnosed dose Fungal infection High-dose hospital hypoxic respiratory failure immunosuppressants Infection morbidity and mortality Patient pulmonary aspergillosis SARS-CoV-2 Secondary infection transferred Treatment worsening [DOI] 10.1016/j.mmcr.2022.01.003 PMC 바로가기 [Article Type] Case Report
Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trialCOVID-19 및 사이토카인 방출 증후군(COV-AID) 징후가 있는 환자에서 항인터루킨 약물의 효과: 요인, 무작위, 대조 시험Randomized Controlled Trial Published on 2021-12-012022-09-12 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 진단, [키워드] 95% CI assessment assigned baseline Belgium Block randomisation blockade C-reactive protein concentration center challenge Clinical improvement Complete Concentration Controlled trial COVID-19 Cytokine release syndrome D-dimer defined diagnosis of COVID-19 discharge drug Effect Efficacy Endpoint EudraCT evaluate Evidence factorial design failure ferritin fraction hazard ratio hospital hospitalised patient hypoxia hypoxic respiratory failure IL-1 IL-6 IL-6 blockade incidence intention-to-treat analysis intention-to-treat population interleukin International intravenously IQR lactate dehydrogenase less lymphopenia male mechanical ventilation median median age median time morbidity and mortality Mortality mortality risk Most patient multicentre Open-label oxygen PaO pathway Patient patients died patients with COVID-19 Primary outcome randomisation randomised Randomly receive Registered Safety safety population SARS-CoV-2 Serious Adverse Event serious infection serum single dose SOFA SOFA score Stratification study groups study outcome supplemental oxygen Symptom syndrome systemic cytokine therapeutic strategy Tocilizumab treatment group Trial were assessed with COVID-19 [DOI] 10.1016/S2213-2600(21)00377-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Response of patients with acute respiratory failure caused by COVID-19 to awake-prone position outside the intensive care unit based on pulmonary involvementObservational Study Published on 2021-11-252022-10-04 Journal: Clinics [Category] MERS, SARS, 임상, [키워드] 95% confidence interval age analyzed body mass index caused characteristic clinical Clinical outcome Comorbidities conducted COVID-19 COVID-19 patient Critical Care Outcome Cutoff cutoff point effective Endotracheal intubation evaluate hazard ratio hospital hypoxic respiratory failure ICU identify IMPROVE intensive care Intervention laboratory data lung median Mortality non-responder noninvasive respiratory Noninvasive ventilation outcome Oxygenation PaO parenchymal damage Patient patients with COVID-19 positive prevent disease progression Prone position prospective observational cohort pulmonary impairment pulmonary involvement reduce mortality Respiratory failure respiratory insufficiency Responder responders response sensitivity Sensitivity and specificity Sex specificity Support the patient Treatment treatments for COVID-19 ventilatory assistance [DOI] 10.6061/clinics/2021/e3368 PMC 바로가기 [Article Type] Observational Study